Electrodes may be oriented across the surface of a compliant or non-compliant expandable angioplasty balloon in a variety of configurations, including in auxetic material patterns typically seen for wires in expandable vascular stents. Application of voltage between positive and negative electrodes will expose the luminal wall to electric fields that will lead to electroporation of the membranes of the cells in the luminal wall if the field strength is sufficient. The agents coating the surface of the balloon may also be charged, allowing for electrophoresis of the agent in addition to electroporation of the intraluminal surface. Reversible and irreversible electroporation and electrophoresis may be applied using the electrode array. The device may additionally contain encapsulation of the agent that is released upon stretch, heating, changes to pH, release of a cofactor, photoactivation, irradiation, or application of electrical fields.